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KMID : 0371320100780030203
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Journal of the Korean Surgical Society
2010 Volume.78 No. 3 p.203 ~ p.206
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Splenic Littoral Cell Angioma with Hepatitis C Associated Liver Cirrhosis
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Koh Young-Wha
Lee Hee-Jin
Huh Joo-Ryung
Park Bong-Hee
Lee Sang-Ryung
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Abstract
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Littoral cell angioma (LCA) of spleen is an uncommon vascular neoplasm of littoral cell origin. It is well established that LCA may be associated with other malignancy or autoimmune disorders. We describe a 34-year-old woman with viral hepatitis C associated liver cirrhosis who presented with the incidental finding of LCA. She showed ascites, esophageal varix and drowsy mentality. Abdominal computed tomography (CT) showed multiple benign looking nodules in both hepatic lobes, but no abnormality in spleen. Liver transplantation and splenectomy were performed. Microscopic findings revealed narrow anastomosing vascular channels lined with plump cells that exfoliated into the lumen. Immunohistochemically the lining cells were positive for CD31, CD68 and negative for CD34, consistent with LCA. Herein, a second case of an incidentally detected LCA with cirrhosis, viral hepatitis C associated in Korea is reported.
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KEYWORD
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Littoral cell angioma, Spleen, Cirrhosis, Hepatitis C
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